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KMID : 0377519810060030417
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Chung-Ang Journal of Medicine
1981 Volume.6 No. 3 p.417 ~ p.420
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Effect of Paragonimus Iloktsuenensis Infection on Tissue Mast Cell of Lung in Albino Rats
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Choi Chang-Uk
Rah Bong-Jin
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Abstract
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In order to observe the changes in number of mast cell in lungs of albino rats against Paragonimus iloktsuenensis infection, rats of three experimental groups were infected with 20 metacercariae of Paragonimus iloktsuenensis, and they were kept for 3 days, 3 weeks and 4 weeks. Right after the each end of the infection period the lung tissues were fixed in 10% neutral formalin and embedded in paraffin. Their sections were stained with Hematoxylin and Eosin for general observation, and toluidine blue for mast cells. All the sections were examined under light microscope and the results obtained were as follows: 1. In the early stages of infection with P. iloktsuenensis there were noticeable changes in lung parenchyma and mast cell numbers in comparing with normal control. 2. After four weeks of infection the invasion of lungflukes into lung parenchyma was noticed. The lesions were represented by thick and fibrosclerotic cavern, granuloma due to eggs, and the increase of peribroncheal lymphatic tissue. A number of mast cell in this infection period were found in these lesions.
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KEYWORD
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